Red CAR macrophages attacking blue cancer cells

The ‘Dead-End’ Immune Cell That Could Make CAR Macrophage Therapy Renewable

Engineered macrophages struggle to expand and persist as cancer therapies. USC researchers found a way to grow their upstream progenitors on a massive scale by blocking one enzyme. CAR-engineered versions attacked leukemia and solid tumors in mice. A new receptor design even recruited the host’s immune system across mismatch barriers.

Alzheimer's sleep habits could impact a woman like this one shown sleeping comfortabley

Hidden Link Between Alzheimer’s and Sleep May Depend on a Single Gene

A large Australian study finds that variants in the AQP4 gene are linked to memory and brain structure in older adults at risk for Alzheimer’s. Sleep quality shaped these effects. Poor sleep worsened brain atrophy and cognitive decline in certain genotypes. The findings point to sleep as a possible way to reduce genetic risk.