Nature is one of the world’s leading peer-reviewed scientific journals, publishing influential research across the biological, physical, chemical and Earth sciences. It is known for studies that deliver major advances in scientific understanding, often highlighting discoveries with broad significance across disciplines and society.
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Prostate cancer cell lines, mouse organoids and mice responded to a two-headed molecule that forces the androgen receptor and the enzyme p300 together. A four-hour dose worked about as well as continuous dosing.
Stanford scientists genetically stripped mouse pups of most of their cortex, then filled the gap with human stem cell derived brain tissue that wired into the mouse’s nervous system and reached its spinal cord.
Two new lab tools push protein engineering in opposite directions at once: one builds proteins nature never made from an expanded genetic alphabet, the other calculates precisely how to destroy a disease protein already causing harm.
Human brain tissue grown from stem cells kept maturing in culture for more than five years, following roughly the same timetable as a real brain. Chemical marks on its DNA recorded how long it had been growing, and older cells remembered which developmental steps they had already completed.
A record breaking JWST observation has turned up a black hole cocooned in gas the size of the solar system, shining 100 billion times brighter than any star could burn. The object may explain the universe’s puzzling little red dots and reveal how the earliest supermassive black holes grew fast.
In mice lacking an autism-linked gene, inhibitory neurons in the hippocampus no longer remodeled themselves after social experience. Boosting a single plasticity gene in those cells, in adult animals, rebalanced the circuit, improved memory, sharpened brain rhythms, and cut seizures from ten of fourteen mice to three of twelve.
Exome sequencing in more than a million people picked out a gene whose rare damaging variants track with lower liver fat, lower blood sugar and a leaner fat distribution. Roughly one person in 7,000 carries one.