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PLOS Medicine

PLOS Medicine publishes articles of general interest on biomedical, environmental, social and political determinants of health. The journal emphasizes work that advances clinical practice, health policy or pathophysiological understanding to benefit health in a variety of settings.

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Creative illustration of butterflies representing thoughts over a brain silhouette.

Brains Aged Faster In Every Condition Tested Except Autism And ADHD, Where The Effect Was Zero

A model trained on 45,900 healthy scans ranked nine disorders by how much older the tissue looked than the birth certificate. Alzheimer’s led at d = 0.97, combined alcohol and tobacco use at 0.84 — and autism and ADHD came in at 0.06 and 0.01, statistically indistinguishable from controls.

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