The goal of Science Translational Medicine is to promote human health by providing a forum for communicating the latest research advances from biomedical, translational, and clinical researchers from all established and emerging disciplines relevant to medicine. In addition to original research, Science Translational Medicine also publishes Reviews, Editorials, Focus articles, and Viewpoints.
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Single-cell sequencing of biopsies from eight people with lupus and seven healthy volunteers pointed to skin cells and a recruited immune cell type that may help explain why ultraviolet light sets off rashes and flares.
Engineered spinal interneurons grown from human stem cells survived inside injured rats, took input from the brainstem and passed signals on to the diaphragm, though every animal needed daily immunosuppression and the gain showed only under respiratory stress.
Removing a glioblastoma from a mouse brain leaves the blood-brain barrier leaky at the surgical rim for two brief spells. A single dose of an approved liposomal chemotherapy, timed into one of them, stopped the tumor coming back.