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Kyushu University researchers were trying to protect HGF, the signal that wakes muscle stem cells, from age-related damage. At double the dose, a small trisulfide compound instead made it grip its receptor twice as tightly as undamaged protein — and nobody yet knows why.
GLP-1 drugs settled the argument that metabolic hormones work. This early-stage candidate, built by AI and delivered as DNA, sketches what round two might look like.
New modelling in Science puts the peak at roughly ten times today’s diversity between 3,000 and 1,000 years ago — and finds the collapse began with the first multinational empires, not European colonialism. The pre-agricultural world, it turns out, had fewer languages than we do now. The authors call it a coarse global model rather than a census.
UCLA researchers found the drug rescued hyperexcitability, sensory over-responsivity and repetitive behavior in adult mice exposed to mild inflammation in the womb — without reversing any of the structural brain changes. The effect was gone by 72 hours, and five weeks of daily treatment produced tolerance.
A new White House science report assembles the metascience case that American research funding has seized up: average age at first NIH grant rose from 36 to 42, drug approvals per billion dollars have fallen eightyfold since 1950, and reviewers scoring the same proposal routinely disagree. It’s a policy document, and it quotes no independent scientists.
Five-minute folk-song sessions three times daily beat guideline-recommended breathing exercises, with older patients and those with severe symptoms responding best.
A University of Guadalajara team found levodopa-treated mice slipped from near-normal forelimb symmetry to 30.4 per cent by day 30, while mice given levodopa plus freeze-dried bee venom held at 50.9. Separate research on beekeepers, who are stung constantly, found no reduced Parkinson’s risk.
A model trained on 45,900 healthy scans ranked nine disorders by how much older the tissue looked than the birth certificate. Alzheimer’s led at d = 0.97, combined alcohol and tobacco use at 0.84 — and autism and ADHD came in at 0.06 and 0.01, statistically indistinguishable from controls.
UMass Amherst researchers trained a legal language model on 34,112 passages from six decades of dissents and found concession rates are entirely unrelated to how harsh a justice sounds.
Two predictors that held nationally collapsed under local modeling, while disability tracked breastfeeding in opposite directions in regions only a few hundred miles apart.
Republican sponsorship predicted antivaccine bills regardless of statehouse control, and vaccine legislation tripled after 2019 as antivaccine measures kept reaching governors’ desks.
In the first adequately powered ARFID trial, family-based treatment moved 98 children from 85.7 to 90.5 per cent of expected body weight while individual therapy left weight flat — but both cut symptoms by the same amount. Every child enrolled was underweight, and 42 per cent of applicants were excluded for not being.